Battles in the bone marrow

Battles in the bone marrow
 
  5:30 pm - 6:30 pm

Coronavirus: Events may be cancelled and venues closed at short notice, you are advised to check on their websites before making a trip.

This is an online video event, please check the organiser for details about how to watch.

Join Professor Cristina Lo Celso as she looks at Leukaemia and blood stem cells under the microscope

During our lifetime blood stem cells produce more cells than there are stars in the universe. However until recently we were unable to reveal the dynamics of these cell factories, encased within bone and inaccessible to direct observation.

Cristina Lo Celso, Professor of Stem Cell Biology at Imperial College London, has pioneered the use of advanced microscopy to delve into our bone marrow and reveal our blood stem cells ecosystem. By using advanced microscopy techniques and applying statistical analyses to large amounts of raw imaging data, her team’s work has uncovered changes in the behaviour of blood stem cells and their surroundings during infections. It has also revealed secrets of how leukaemia cells infiltrate bone marrow in response to chemotherapy destroying the niches that would normally support healthy blood production.

In her inaugural lecture she will discuss the implication of these discoveries, including for improved leukaemia treatment, and highly relevant to current events, for the longer-term impacts of severe infections. She will also reflect on how her microscopy-driven work has developed through unique collaborations with physicists and mathematical modellers, and its future promise in answering fundamental questions in stem cell biology, such as how a tissue regenerates to maintain organ functionality throughout our lives.

Biography

Cristina Lo Celso graduated from Torino University in Italy. She obtained her PhD from UCL, working with Fiona Watt at the CRUK London Research Institute, where she studied epidermal stem cells. She started performing intravital microscopy of the haematopoietic stem cell (HSC) niche during her postdoctoral training at Harvard University with David Scadden. In 2009 she started her independent research group at Imperial College London, where she is now a professor in the department of Life Sciences, and one of the network leads of the Imperial Stem Cell and Regenerative Medicine Network.

Prof. Lo Celso recently established a satellite laboratory at the Sir Francis Crick Institute. Her research aims to understand the mechanisms regulating HSC function during steady state and during stresses such as infections, leukaemia and transplantation. Her interdisciplinary approach combines mouse bone marrow intravital microscopy techniques, computational image analysis, molecular profiling and mathematical modelling of the HSC niche. Prof. Lo Celso is the first woman to receive the Foulkes Medal award (2017), received the ISEH New Investigator award in 2017, presented the DGZ Carl Zeiss Lecture 2018 and received the Royal Microscopical Society Life Sciences Medal 2019.

Cost: Free of Charge


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2021-01-13 17:30 2021-01-13 17:30 Europe/London Battles in the bone marrow Join Professor Cristina Lo Celso as she looks at Leukaemia and blood stem cells under the microscope https://www.ianvisits.co.uk/calendar/2021/01/13/battles-in-the-bone-marrow-250286 ,,,

This is an online video event, please check the organiser for details about how to watch.

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