Because 2012 predictions are so mainstream…
The French will increase their involvement in the War of the Holy League and probably defeat the Spanish at some point.
With the assistance of the Papal Army, the Medicis will capture Florence again. Expectations that the Republic’s Secretary Niccolò Machiavelli will leave to write a book.
After several years delay, the Pope will finally attend the Fifth Council of the Lateran
After pressure to allow them to see Michelangelo’s painting, the public will be allowed into the Sistine Chapel for the first time.
The ongoing strife between father and son at the apex of the Ottoman Empire will result in the abdication of Bayezid II, and the enthronement of Selim I as the new Sultan.
James IV of Scotland Margaret Tudor with give birth to a future King of Scotland (to be fair, she is already pregnant, so this isn’t that risky a prediction to make!)
The Spanish government will finally break with sensible Christian thinking and pass laws granting rights to mere heathens in the Americas. Lets all hope that doesn’t happen – granting rights to heathens indeed!